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Article

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor.

Nature - 24 Feb 2011

Ressler Kerry J, Mercer Kristina B, Bradley Bekh, Jovanovic Tanja, Mahan Amy, Kerley Kimberly, Norrholm Seth D, Kilaru Varun, Smith Alicia K, Myers Amanda J, Ramirez Manuel, Engel Anzhelika, Hammack Sayamwong E, Toufexis Donna, Braas Karen M, Binder Elisabeth B, May Victor

Abstract excerpt

Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the cellular stress response. In contrast, it is unclear if the PACAP-PAC1 receptor pathway has a role in human psychological stress responses, such as post-traumatic stress disorder (PTSD). Here we find, in heavily traumatized subjects, a sex-specific association of PACAP blood levels with fear physiology, PTSD diagnosis and...

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Share to Amygdala
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21350482
DOI: 10.1038/nature09856
PMCID: PMC3046811

Genes

ADCYAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor.PMID 21350482Read ↗

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ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females.Semantic proximity Read ↗

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Neural Mechanism of a Sex-Specific Risk Variant for Posttraumatic Stress Disorder in the Type I Receptor of the Pituitary Adenylate Cyclase Activating Polypeptide.Semantic proximity Read ↗

Association of Posttraumatic Stress Disorder With rs2267735 in the ADCYAP1R1 Gene: A Meta-Analysis.Semantic proximity Read ↗

Circulating PACAP peptide and PAC1R genotype as possible transdiagnostic biomarkers for anxiety disorders in women: a preliminary study.Semantic proximity Read ↗

Sex-Specific Regulation of Behavioral Responses to Single Prolonged Stress: Role of PACAPSemantic proximity Read ↗

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