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Article

Functional evaluation of a PTSD-associated genetic variant: estradiol regulation and ADCYAP1R1.

Translational psychiatry - 13 Dec 2016

Mercer K B, Dias B, Shafer D, Maddox S A, Mulle J G, Hu P, Walton J, Ressler K J

Abstract excerpt

Posttraumatic stress disorder (PTSD) affects 5-10% percent of the US adult population with a higher prevalence among women compared with men. Although it remains unclear how biological sex associates with susceptibility to PTSD, one mechanism may involve a role for estrogen in a gene by environment interaction. We previously demonstrated a sex-dependent association between the pituitary adenylate...

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Identifiers

PMID: 27959335
DOI: 10.1038/tp.2016.241
PMCID: PMC5290337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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