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AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation

13 Aug 2018

Abstract excerpt

Abstract A high prevalence of adherent-invasive E. coli (AIEC) in the intestinal mucosa of Crohn’s disease patients has been shown. AIEC colonize the intestine and induce inflammation in genetically predisposed mouse models including CEABAC10 transgenic (Tg) mice expressing human CEACAM6-receptor for AIEC and eif2ak4−/− mice exhibiting autophagy defect in response to AIEC infection. Here, we aimed at...

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PMID: 30120269
DOI: 10.1038/s41598-018-30055-y

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