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Article

Chromosomal alterations among age-related haematopoietic clones in Japan.

Nature - 1 Aug 2020

Terao Chikashi, Suzuki Akari, Momozawa Yukihide, Akiyama Masato, Ishigaki Kazuyoshi, Yamamoto Kazuhiko, Matsuda Koichi, Murakami Yoshinori, McCarroll Steven A, Kubo Michiaki, Loh Po-Ru, Kamatani Yoichiro

Abstract excerpt

The extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Haematopoietic clones with acquired mutations become common with advancing age and can lead to blood cancers1-10. Here we describe shared and population-specific patterns of genomic mutations and clonal selection in haematopoietic cells on the basis of 33,250 autosomal mosaic chromosomal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32581364
DOI: 10.1038/s41586-020-2426-2
PMCID: PMC7489641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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