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Article

No Evidence That Genetic Variation at the Klotho Locus Is Associated With Longevity in Caucasians from the Newcastle 85+ Study and the UK Biobank.

The journals of gerontology. Series A, Biological sciences and medical sciences - 3 Mar 2022

Amin Hasnat A, Cordell Heather J, Martin-Ruiz Carmen, Robinson Louise, Kirkwood Tom, Blakemore Alexandra I, Drenos Fotios

Abstract excerpt

The demographics of Western populations are changing, with an increase in the proportion of older adults. There is evidence to suggest that genetic factors may influence the aging process: studying these may lead to interventions to help individuals live a longer and healthier life. Evidence from several groups indicates that Klotho (KL), a gene encoding a single-pass transmembrane protein that acts as an FGF23...

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PMID: 34893828
DOI: 10.1093/gerona/glab361
PMCID: PMC8893196

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No Evidence That Genetic Variation at the Klotho Locus Is Associated With Longevity in Caucasians from the Newcastle 85+ Study and the UK Biobank.PMID 34893828Read ↗

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The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study.Semantic proximity Read ↗

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