Article
Ancestry effects on type 2 diabetes genetic risk inference in Hispanic/Latino populations.
BMC medical genetics - 25 Jun 2020
Chande Aroon T, Rishishwar Lavanya, Conley Andrew B, Valderrama-Aguirre Augusto, Medina-Rivas Miguel A, Jordan I King
Abstract excerpt
BACKGROUND: Hispanic/Latino (HL) populations bear a disproportionately high burden of type 2 diabetes (T2D). The ability to predict T2D genetic risk using polygenic risk scores (PRS) offers great promise for improved screening and prevention. However, there are a number of complications related to the accurate inference of genetic risk across HL populations with distinct ancestry profiles. We investigated how...
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