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Article

Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population.

PloS one - 1 Jan 2012

Campbell Desmond D, Parra Maria V, Duque Constanza, Gallego Natalia, Franco Liliana, Tandon Arti, Hünemeier Tábita, Bortolini Cátira, Villegas Alberto, Bedoya Gabriel, McCarthy Mark I, Price Alkes, Reich David, Ruiz-Linares Andrés

Abstract excerpt

The "thrifty genotype" hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle. However, identification of the gene variants underpinning this hypothesis remains elusive. Here we assessed the role of Native American ancestry, socioeconomic status...

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Identifiers

PMID: 22529894
DOI: 10.1371/journal.pone.0033570
PMCID: PMC3328483

Genes

ABCA1
CDKAL1
KCNQ1
RBMS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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