Article
The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.
Diabetologia - 1 Jul 2023
Huerta-Chagoya Alicia, Schroeder Philip, Mandla Ravi, Deutsch Aaron J, Zhu Wanying, Petty Lauren, Yi Xiaoyan, Cole Joanne B, Udler Miriam S, Dornbos Peter, Porneala Bianca, DiCorpo Daniel, Liu Ching-Ti, Li Josephine H, Szczerbiński Lukasz, Kaur Varinderpal, Kim Joohyun, Lu Yingchang, Martin Alicia, Eizirik Decio L, Marchetti Piero, Marselli Lorella, Chen Ling, Srinivasan Shylaja, Todd Jennifer, Flannick Jason, Gubitosi-Klug Rose, Levitsky Lynne, Shah Rachana, Kelsey Megan, Burke Brian, Dabelea Dana M, Divers Jasmin, Marcovina Santica, Stalbow Lauren, Loos Ruth J F, Darst Burcu F, Kooperberg Charles, Raffield Laura M, Haiman Christopher, Sun Quan, McCormick Joseph B, Fisher-Hoch Susan P, Ordoñez Maria L, Meigs James, Baier Leslie J, González-Villalpando Clicerio, González-Villalpando Maria Elena, Orozco Lorena, García-García Lourdes, Moreno-Estrada Andrés, Aguilar-Salinas Carlos A, Tusié Teresa, Dupuis Josée, Ng Maggie C Y, Manning Alisa, Highland Heather M, Cnop Miriam, Hanson Robert, Below Jennifer, Florez Jose C, Leong Aaron, Mercader Josep M
Abstract excerpt
AIMS/HYPOTHESIS: The Latino population has been systematically underrepresented in large-scale genetic analyses, and previous studies have relied on the imputation of ungenotyped variants based on the 1000 Genomes (1000G) imputation panel, which results in suboptimal capture of low-frequency or Latino-enriched variants. The National Heart, Lung, and Blood Institute (NHLBI) Trans-Omics for Precision Medicine...
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