Article
Epigenomically Bistable Regions across Neuron-Specific Genes Govern Neuron Eligibility to a Coding Ensemble in the Hippocampus.
Cell reports - 23 Jun 2020
Odell Shannon C, Taki Faten, Klein Shifra Liba, Chen Rosa J, Levine Olivia B, Skelly Mary Jane, Nabila Anika, Brindley Elizabeth, Gal Toth Judit, Dündar Friederike, Sheridan Caroline K, Fetcho Robert N, Alonso Alicia, Liston Conor, Landau Dan A, Pleil Kristen E, Toth Miklos
Abstract excerpt
Sensory inputs activate sparse neuronal ensembles in the dentate gyrus of the hippocampus, but how eligibility of individual neurons to recruitment is determined remains elusive. We identify thousands of largely bistable (CpG methylated or unmethylated) regions within neuronal gene bodies, established during mouse dentate gyrus development. Reducing DNA methylation and the proportion of the methylated epialleles...
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