Article

Neuron-specific chromatin disruption at CpG islands and aging-related regions in Kabuki syndrome mice

2023-08-03

Abstract excerpt

Many Mendelian developmental disorders caused by coding variants in epigenetic regulators have now been discovered. Epigenetic regulators are broadly expressed, and each of these disorders typically exhibits phenotypic manifestations from many different organ systems. An open question is whether the chromatin disruption – the root of the pathogenesis – is similar in the different disease-relevant cell types. This...

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Literature Corpus work: 58ea3d88-714d-5e07-b69f-5b9a3c7c9aee
DOI: 10.1101/2023.08.01.551456

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