Article

Targeting de novo purine biosynthesis for tuberculosis treatment

2024-09-05

Abstract excerpt

<title>Abstract</title> <p>Tuberculosis remains the leading cause of death from an infectious disease, responsible for 1.3 million deaths annually. Here, we report the discovery of a first-in-class small molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway. Our lead candidate, JNJ-6640, exhibited nanomolar bactericidal activity in vitro. Using an array of co...

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Literature Corpus work: 7a671d19-d12e-5605-a98a-c62ba9b2c6d3
DOI: 10.21203/rs.3.rs-4913610/v1

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