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Article

MicroRNA 122 Affects both the Initiation and the Maintenance of Hepatitis C Virus Infections.

Journal of virology - 23 Feb 2022

Panigrahi Mamata, Thibault Patricia A, Wilson Joyce A

Abstract excerpt

A liver-specific microRNA, miR-122, anneals to the hepatitis C virus (HCV) genomic 5' terminus and is essential for virus replication in cell culture. However, bicistronic HCV replicons and full-length RNAs with specific mutations in the 5' untranslated region (UTR) can replicate, albeit to low levels, without miR-122. In this study, we have identified that HCV RNAs lacking the structural gene region or having...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34908444
DOI: 10.1128/JVI.01903-21
PMCID: PMC8865533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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