Article
Expression of microRNA miR-122 facilitates an efficient replication in nonhepatic cells upon infection with hepatitis C virus.
Journal of virology - 1 Aug 2012
Fukuhara Takasuke, Kambara Hiroto, Shiokawa Mai, Ono Chikako, Katoh Hiroshi, Morita Eiji, Okuzaki Daisuke, Maehara Yoshihiko, Koike Kazuhiko, Matsuura Yoshiharu
Abstract excerpt
Hepatitis C virus (HCV) is one of the most common etiologic agents of chronic liver diseases, including liver cirrhosis and hepatocellular carcinoma. In addition, HCV infection is often associated with extrahepatic manifestations (EHM), including mixed cryoglobulinemia and non-Hodgkin's lymphoma. However, the mechanisms of cell tropism of HCV and HCV-induced EHM remain elusive, because in vitro propagation of HCV...
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