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Article

Do common dopaminergic variants modulate processing speed in cognitive aging? A longitudinal candidate gene study.

PloS one - 1 Jan 2026

Rose Monica Anona, Robinson Andrew C, Payton Antony

Abstract excerpt

Amid a global shift toward older populations, understanding the mechanisms of cognitive aging is a public health priority. Processing speed shows age-related decline and predicts dementia risk. Neuroimaging links dopaminergic system integrity to cognitive performance in aging, but the contribution of common genetic variation remains unclear. This study tested whether common dopaminergic variants influence 12-year...

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Share to Longitudinal Studies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 42467707
DOI: 10.1371/journal.pone.0353790
PMCID: PMC13379125

Genes

DRD2
DBH
COMT
DDC
DRD1
SLC6A3
TH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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