Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making.

Critical reviews in oncogenesis - 1 Jan 2011

Mangan James K, Speck Nancy A

Abstract excerpt

Translocations and mutations in the core binding factor genes, RUNX1 or CBFB, are found in acute myeloid and lymphocytic leukemia, therapy-related myeloid leukemia, myelodysplastic syndrome, chronic myelomonocytic leukemia, and in familial platelet disorder with predisposition to acute myeloid leukemia. Here we review the biochemical and biological properties of the normal Runx1 protein, discuss the nature of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 2 Subunit
Share to RUNX1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Myelodysplastic Syndromes

Share to Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 22150309
DOI: 10.1615/critrevoncog.v16.i1-2.80
PMCID: PMC3248792

Genes

RUNX1
CBFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making.PMID 22150309Read ↗

The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies.Semantic proximity Read ↗

RUNX1 and CBFβ Mutations and Activities of Their Wild-Type Alleles in AML.Semantic proximity Read ↗

Molecular Basis of Hematological Disease Caused by Inherited or Acquired RUNX1 Mutations.Semantic proximity Read ↗

RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia.Semantic proximity Read ↗

Molecular findings in myeloid neoplasms.Semantic proximity Read ↗

RUNX1 mutations in pediatric acute myeloid leukemia are associated with distinct genetic features and an inferior prognosisSemantic proximity Read ↗

Role of RUNX1 in hematological malignanciesSemantic proximity Read ↗

Distinct clonal anomalies involving RUNX1 in acute myeloid leukemia at diagnosis and after bone marrow transplantation.Semantic proximity Read ↗

RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features.Semantic proximity Read ↗

RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes.Semantic proximity Read ↗

Impact of U2AF1 Pathogenic Variants on Prognosis of Myelodysplastic Neoplasms With RUNX1 Mutation.Semantic proximity Read ↗

Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.