Article
Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.
Nature microbiology - 1 Sept 2020
Hughes David A, Bacigalupe Rodrigo, Wang Jun, Rühlemann Malte C, Tito Raul Y, Falony Gwen, Joossens Marie, Vieira-Silva Sara, Henckaerts Liesbet, Rymenans Leen, Verspecht Chloë, Ring Susan, Franke Andre, Wade Kaitlin H, Timpson Nicholas J, Raes Jeroen
Abstract excerpt
Recent population-based1-4 and clinical studies5 have identified a range of factors associated with human gut microbiome variation. Murine quantitative trait loci6, human twin studies7 and microbiome genome-wide association studies1,3,8-12 have provided evidence for genetic contributions to microbiome composition. Despite this, there is still poor overlap in genetic association across human studies. Using...
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