Article
Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation.
Nature genetics - 1 Mar 2026
Dekkers Koen F, Pertiwi Kamalita, Baldanzi Gabriel, Lundmark Per, Hammar Ulf, Moksnes Marta Riise, Coward Eivind, Nethander Maria, Salih Ghassan Ali, Miari Mariam, Nguyen Diem, Sayols-Baixeras Sergi, Eklund Aron C, Holm Jacob Bak, Nielsen H Bjørn, Volpiano Camila Gazolla, Méric Guillaume, Thangam Manonanthini, Hakaste Liisa, Tuomi Tiinamaija, Ahlqvist Emma, Smith Christopher A, Allen Marie, Reimann Frank, Gribble Fiona M, Ohlsson Claes, Hveem Kristian, Melander Olle, Nilsson Peter M, Engström Gunnar, Smith J Gustav, Michaëlsson Karl, Ärnlöv Johan, Orho-Melander Marju, Fall Tove
Abstract excerpt
Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1-OR51E2 locus, encoding...
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