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Article

Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in the gut epithelium

22 Jun 2020

Abstract excerpt

Objective The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe inflammatory diseases, but the responsiveness of GI epithelial cells to bacterial stimulation remains unclear. Design We generated 42 lines of human and murine organoids from gastric and intestinal segments of both adult...

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PMID: 32571970
DOI: 10.1136/gutjnl-2019-319919

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