Article

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system

2020-10-07

Abstract excerpt

The intestinal epithelium is a primary interface for engagement of the host response by foodborne pathogens, like Salmonella enterica serovar Typhimurium (STm). While interaction of STm with the mammalian host has been well studied in vitro in transformed epithelial cell lines or in the complex intestinal environment in vivo , few tractable models recapitulate key features of the intestinal epithelium. Human in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98e166d9-d147-59ec-838f-a83c8b8e92e7
DOI: 10.1101/2020.10.05.327551

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model systemDOI 10.1101/2020.10.05.327551Read

Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoidsSemantic proximity Read

SPI2 T3SS effectors facilitate enterocyte apical to basolateral transmigration of Salmonella -containing vacuoles in vivoSemantic proximity Read

A Versatile Human Intestinal Organoid-Derived Epithelial Monolayer Model for the Study of Enteric PathogensSemantic proximity Read

Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal TissueSemantic proximity Read

Research in a time of enteroids and organoids: how the human gut model has transformed the study of enteric bacterial pathogensSemantic proximity Read

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivoSemantic proximity Read

Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells.Semantic proximity Read

Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fireSemantic proximity Read

Cross-Talk Between the Intestinal Epithelium and Salmonella TyphimuriumSemantic proximity Read

An Advanced Human Intestinal Coculture Model Reveals Compartmentalized Host and Pathogen Strategies during Salmonella InfectionSemantic proximity Read

Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gutSemantic proximity Read

Spheres of Influence: Insights into Salmonella Pathogenesis from Intestinal OrganoidsSemantic proximity Read