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Article

Role of Disulfide Bonds in Regulating Antigen Processing and Epitope Selection

1 Sept 2002

Abstract excerpt

Knowledge of the events governing Ag processing and epitope selection within APC is key to the development of novel immunotherapeutic strategies for infectious diseases, cancer, and autoimmunity. The influence of disulfides and Ag reduction on the hierarchy of epitope presentation via MHC class II molecules was investigated through studies of a self Ag, IgG kappa. HLA-DR4(+) B cells preferentially present an...

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PMID: 12193713
DOI: 10.4049/jimmunol.169.5.2444

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