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Article

The C-terminal cysteines in zinc transporter 8 (ZnT8) form an independent epitope for autoantibody binding in newly diagnosed type 1 diabetes.

Clinical and experimental immunology - 6 Jan 2026

Williams Claire L, Rokni S, Lampasona V, Brigatti C, Gillard B T, Gillespie K M, Williams A J K, Long A E

Abstract excerpt

Autoantibodies to zinc transporter 8 (ZnT8A) are important diagnostic and predictive markers for type 1 diabetes (T1D). Current methods to detect ZnT8A use C-terminal ZnT8 (aa268-369). Previous research identified three major ZnT8A epitopes (R325, W325, and a four-residue conformational epitope [R332/E333/K336/K340]), but the human-specific cysteine region has not been investigated. We sought to examine ZnT8A...

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Topics

Humans
Diabetes Mellitus, Type 1
Zinc Transporter 8
Cysteine
Epitopes
Autoantibodies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Protein Binding

Mutation

Source

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Identifiers

PMID: 42671000
DOI: 10.1093/cei/uxag050
PMCID: PMC13537458

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