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Article

Mutation profiling of chronic myeloproliferative neoplasms: improving clinical-molecular prognostic models.

Expert review of molecular diagnostics - 1 Nov 2025

Loscocco Giuseppe G, Gangat Naseema, Guglielmelli Paola, Vannucchi Alessandro M, Tefferi Ayalew

Abstract excerpt

INTRODUCTION: Classic myeloproliferative neoplasms (MPN), comprising polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF), both primary and secondary to PV and ET, are clonal hematopoietic disorders characterized by abnormal proliferation of largely mature cells, commonly associated with JAK2, CALR, or MPL mutations. These mutations result in the constitutive activation of the JAK-STAT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41074259
DOI: 10.1080/14737159.2025.2573466

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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