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Article

Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes.

Physiological genomics - 1 Jul 2020

Dainis Alexandra, Zaleta-Rivera Kathia, Ribeiro Alexandre, Chang Andrew Chia Hao, Shang Ching, Lan Feng, Burridge Paul W, Liu W Robert, Wu Joseph C, Chang Alex Chia Yu, Pruitt Beth L, Wheeler Matthew, Ashley Euan

Abstract excerpt

Allele-specific RNA silencing has been shown to be an effective therapeutic treatment in a number of diseases, including neurodegenerative disorders. Studies of allele-specific silencing in hypertrophic cardiomyopathy (HCM) to date have focused on mouse models of disease. We here examine allele-specific silencing in a human-cell model of HCM. We investigate two methods of silencing, short hairpin RNA (shRNA) and...

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Share to Cardiac Myosins
Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Induced Pluripotent Stem Cells

Share to Myocytes, Cardiac

Share to Myosin Heavy Chains

Share to Oligonucleotides, Antisense

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Source

Open in PubMed Open full text

Identifiers

PMID: 32567507
DOI: 10.1152/physiolgenomics.00021.2020
PMCID: PMC7468691

Genes

MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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