Article

Cardiomyocyte apoptosis contributes to contractile dysfunction in stem cell model of <i>MYH7</i> E848G hypertrophic cardiomyopathy

2023-01-25

Abstract excerpt

Missense mutations in myosin heavy chain 7 ( MYH7 ) are a common cause of hyper-trophic cardiomyopathy (HCM), but the molecular mechanisms underlying MYH7 -based HCM remain unclear. In this work, we generated cardiomyocytes derived from isogenic human induced pluripotent stem cells to model the heterozygous pathogenic MYH7 missense variant, E848G, which is associated with left ventricular hypertrophy and adulto...

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Literature Corpus work: 15780e4f-4a91-5d82-a964-d97969a883ee
DOI: 10.1101/2023.01.24.525458

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