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Article

Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells.

Cardiovascular research - 1 Nov 2014

Han Lu, Li Yang, Tchao Jason, Kaplan Aaron D, Lin Bo, Li You, Mich-Basso Jocelyn, Lis Agnieszka, Hassan Narmeen, London Barry, Bett Glenna C L, Tobita Kimimasa, Rasmusson Randall L, Yang Lei

Abstract excerpt

AIMS: Familial hypertrophic cardiomyopathy (HCM) is one the most common heart disorders, with gene mutations in the cardiac sarcomere. Studying HCM with patient-specific induced pluripotent stem-cell (iPSC)-derived cardiomyocytes (CMs) would benefit the understanding of HCM mechanism, as well as the development of personalized therapeutic strategies. METHODS AND RESULTS: To investigate the molecular mechanism...

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Source

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Identifiers

PMID: 25209314
DOI: 10.1093/cvr/cvu205
PMCID: PMC4217687

Genes

MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells.PMID 25209314Read ↗

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