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Article

Genotype-Dependent Effects of Mechanical Stretch and GATA4-Targeted Compound 3i-1262 in Cardiomyopathy Patient-Derived hiPSC-Cardiomyocytes.

Basic & clinical pharmacology & toxicology - 1 Sept 2026

Pohjavaara Saana, Kinnunen Sini M, Ruskoaho Heikki, Aalto-Setälä Katriina, Välimäki Mika J, Talman Virpi

Abstract excerpt

Genetic hypertrophic and dilated cardiomyopathies (HCM and DCM, respectively) are characterised by structural and functional abnormalities that can lead to heart failure. However, current therapies mainly reduce symptoms. Patient-derived human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes provide a valuable platform to study genotype-specific pathophysiology and pharmacology. We subjected...

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Topics

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Share to Cardiac Myosins
Share to Cardiomyopathy, Dilated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Hypertrophic

Share to GATA4 Transcription Factor

Share to Lamin Type A

Share to Myocytes, Cardiac

Share to Myosin Heavy Chains

Share to Stress, Mechanical

Source

Open in PubMed Open full text

Identifiers

PMID: 42611695
DOI: 10.1111/bcpt.70284
PMCID: PMC13484559

Genes

MYH7
NPPB
GATA4
NPPA
CSRP3
GAL
LMNA
MYBPC3
SLC16A9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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