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Article

Cardiomyocyte Apoptosis Is Associated with Contractile Dysfunction in Stem Cell Model of MYH7 E848G Hypertrophic Cardiomyopathy.

International journal of molecular sciences - 3 Mar 2023

Loiben Alexander M, Chien Wei-Ming, Friedman Clayton E, Chao Leslie S-L, Weber Gerhard, Goldstein Alex, Sniadecki Nathan J, Murry Charles E, Yang Kai-Chun

Abstract excerpt

Missense mutations in myosin heavy chain 7 (MYH7) are a common cause of hypertrophic cardiomyopathy (HCM), but the molecular mechanisms underlying MYH7-based HCM remain unclear. In this work, we generated cardiomyocytes derived from isogenic human induced pluripotent stem cells to model the heterozygous pathogenic MYH7 missense variant, E848G, which is associated with left ventricular hypertrophy and adult-onset...

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Source

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Identifiers

PMID: 36902340
DOI: 10.3390/ijms24054909
PMCID: PMC10003263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cardiomyocyte Apoptosis Is Associated with Contractile Dysfunction in Stem Cell Model of MYH7 E848G Hypertrophic Cardiomyopathy.PMID 36902340Read ↗

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