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Capturing transient antibody conformations with DNA origami epitopes

19 Jun 2020

Abstract excerpt

Revealing antibody-antigen interactions at the single-molecule level will deepen our understanding of immunology. However, structural determination under crystal or cryogenic conditions does not provide temporal resolution for resolving transient, physiologically or pathologically relevant functional antibody-antigen complexes. Here, we develop a triangular DNA origami framework with site-specifically anchored...

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Share to Advanced biosensing and bioanalysis techniques
Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 32561744
DOI: 10.1038/s41467-020-16949-4

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