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Article

Shear Stress Induces Phenotypic Modulation of Vascular Smooth Muscle Cells via AMPK/mTOR/ULK1-Mediated Autophagy.

Cellular and molecular neurobiology - 1 Mar 2018

Sun Liqian, Zhao Manman, Liu Aihua, Lv Ming, Zhang Jingbo, Li Youxiang, Yang Xinjian, Wu Zhongxue

Abstract excerpt

Phenotypic modulation of vascular smooth muscle cells (VSMCs) is involved in the pathophysiological processes of the intracranial aneurysms (IAs). Although shear stress has been implicated in the proliferation, migration, and phenotypic conversion of VSMCs, the molecular mechanisms underlying these events are currently unknown. In this study, we investigated whether shear stress(SS)-induced VSMC phenotypic...

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Share to AMP-Activated Protein Kinase Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 28560556
DOI: 10.1007/s10571-017-0505-1

Genes

ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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