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Article

Mono-PEGylation of a Thermostable Arginine-Depleting Enzyme for the Treatment of Lung Cancer.

International journal of molecular sciences - 14 Jun 2020

Chung Sai-Fung, Kim Chi-Fai, Kwok Sui-Yi, Tam Suet-Ying, Chen Yu Wai, Chong Hiu-Chi, Leung Siu-Lun, So Pui-Kin, Wong Kwok-Yin, Leung Yun-Chung, Lo Wai-Hung

Abstract excerpt

L-arginine (L-Arg) depletion induced by randomly PEGylated arginine deiminase (ADI-PEG20) can treat arginosuccinate synthase (ASS)-negative cancers, and ADI-PEG20 is undergoing phase III clinical trials. Unfortunately, ASS-positive cancers are resistant to ADI-PEG20. Moreover, the yield of ADI production is low because of the formation of inclusion bodies. Here, we report a thermostable arginine-depleting enzyme,...

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Identifiers

PMID: 32545874
DOI: 10.3390/ijms21124234
PMCID: PMC7353006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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