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Article

Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants.

Molecular cell - 16 May 2024

Yang Chao, Pataskar Abhijeet, Feng Xiaodong, Montenegro Navarro Jasmine, Paniagua Inés, Jacobs Jacqueline J L, Zaal Esther A, Berkers Celia R, Bleijerveld Onno B, Agami Reuven

Abstract excerpt

Many types of human cancers suppress the expression of argininosuccinate synthase 1 (ASS1), a rate-limiting enzyme for arginine production. Although dependency on exogenous arginine can be harnessed by arginine-deprivation therapies, the impact of ASS1 suppression on the quality of the tumor proteome is unknown. We therefore interrogated proteomes of cancer patients for arginine codon reassignments...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38759626
DOI: 10.1016/j.molcel.2024.04.012
PMCID: PMC11129317

Genes

KEAP1
ASS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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