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Article

A Recombinant Targeted Bionanoparticle In Vitro Expressing a Gene-Editing Protein for Epidermal Growth Factor Receptor Mutant Lung Cancer.

ACS nano - 17 Feb 2026

Ren Yuxin, Xu Jiarui, Luo Qian, Li Peishan, Jiang Min, Cheng Yuntao, Zhang Hongrui, Wei Dingyi, Bai Wenjing, Liu Sunan, Wang Guiling, Xie Ying, Li Jianwei, Lu Wanliang

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutation is a significant driving factor in the occurrence and progression of lung cancer. How to effectively block the abnormal expression of EGFR remains a key issue that urgently needs to be addressed, as it is of vital importance for the effective treatment of this cancer. Here, we report a recombinant targeted bionanoparticle that in vitro expresses Cas9 protein...

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Share to CRISPR-Associated Protein 9
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41645678
DOI: 10.1021/acsnano.5c17709
PMCID: PMC12919578

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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