Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort.

HGG advances - 13 Jul 2023

Zaidi Arslan A, Verma Anurag, Morse Colleen, Ritchie Marylyn D, Mathieson Iain

Abstract excerpt

Mitochondrial DNA copy number (mtCN) is often treated as a proxy for mitochondrial (dys-) function and disease risk. Pathological changes in mtCN are common symptoms of rare mitochondrial disorders, but reported associations between mtCN and common diseases vary across studies. To understand the biology of mtCN, we carried out genome- and phenome-wide association studies of mtCN in 30,666 individuals from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Copy Number Variations
Share to DNA, Mitochondrial
Share to Leukocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 37255673
DOI: 10.1016/j.xhgg.2023.100202
PMCID: PMC10225932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort.PMID 37255673Read ↗

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohortSemantic proximity Read ↗

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortalitySemantic proximity Read ↗

Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation.Semantic proximity Read ↗

Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.Semantic proximity Read ↗

GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 73 loci and highlights a potential causal role in dementiaSemantic proximity Read ↗

Nuclear genetic control of mtDNA copy number and heteroplasmy in humansSemantic proximity Read ↗

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.Semantic proximity Read ↗

Whole-exome sequencing in 415,422 individuals identifies rare variants associated with mitochondrial DNA copy numberSemantic proximity Read ↗

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differencesSemantic proximity Read ↗

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.Semantic proximity Read ↗

A Bioinformatics Pipeline for Estimating Mitochondria DNA Copy Number and Heteroplasmy Levels from Whole Genome Sequencing DataSemantic proximity Read ↗

Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.