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Article

The secondary-structured DNA-binding activity of Dna2 endonuclease/helicase is critical to cell growth under replication stress.

The FEBS journal - 1 Feb 2021

Park Soyeong, Karatayeva Nargis, Demin Annie Albert, Munashingha Palinda Ruvan, Seo Yeon-Soo

Abstract excerpt

Dna2 can efficiently process 5' flaps containing DNA secondary structure using coordinated action of the three biochemical activities: the N-terminally encoded DNA-binding activity and the C-terminally encoded endonuclease and helicase activities. In this study, we investigated the cross talk among the three functional domains using a variety of dna2 mutant alleles and enzymes derived thereof. We found that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32638513
DOI: 10.1111/febs.15475
PMCID: PMC7984218

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