Article
Determinants of RNA recognition by the FinO domain of the Escherichia coli ProQ protein.
Nucleic acids research - 27 Jul 2020
Stein Ewa M, Kwiatkowska Joanna, Basczok Maciej M, Gravel Chandra M, Berry Katherine E, Olejniczak Mikołaj
Abstract excerpt
The regulation of gene expression by small RNAs in Escherichia coli depends on RNA binding proteins Hfq and ProQ, which bind mostly distinct RNA pools. To understand how ProQ discriminates between RNA substrates, we compared its binding to six different RNA molecules. Full-length ProQ bound all six RNAs similarly, while the isolated N-terminal FinO domain (NTD) of ProQ specifically recognized RNAs with...
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