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Article

Improving the gene-regulation ability of small RNAs by scaffold engineering in Escherichia coli.

ACS synthetic biology - 21 Mar 2014

Sakai Yuta, Abe Koichi, Nakashima Saki, Yoshida Wataru, Ferri Stefano, Sode Koji, Ikebukuro Kazunori

Abstract excerpt

Noncoding small RNAs are involved in transcriptional and post-transcriptional gene regulation of target mRNAs by modulating mRNA elongation, stability, or translational efficiency. Many natural trans-encoded small RNAs contain a scaffold that allows binding of the RNA chaperone protein Hfq for conditional gene regulation. Here, we improved the gene regulation abilities of small RNAs by directly fusing the natural...

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PMID: 24328142
DOI: 10.1021/sb4000959

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