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Article

Acidic Residues in the Hfq Chaperone Increase the Selectivity of sRNA Binding and Annealing.

Journal of molecular biology - 6 Nov 2015

Panja Subrata, Santiago-Frangos Andrew, Schu Daniel J, Gottesman Susan, Woodson Sarah A

Abstract excerpt

Hfq facilitates gene regulation by small non-coding RNAs (sRNAs), thereby affecting bacterial attributes such as biofilm formation and virulence. Escherichia coli Hfq recognizes specific U-rich and AAN motifs in sRNAs and target mRNAs, after which an arginine patch on the rim promotes base pairing between their complementary sequences. In the cell, Hfq must discriminate between many similar RNAs. Here, we report...

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Identifiers

PMID: 26196441
DOI: 10.1016/j.jmb.2015.07.010
PMCID: PMC4624489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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