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Article

Escherichia coli Hfq has distinct interaction surfaces for DsrA, rpoS and poly(A) RNAs.

Nature structural & molecular biology - 1 Dec 2004

Mikulecky Peter J, Kaw Meenakshi K, Brescia Cristin C, Takach Jennifer C, Sledjeski Darren D, Feig Andrew L

Abstract excerpt

The bacterial Sm-like protein Hfq facilitates RNA-RNA interactions involved in post-transcriptional regulation of the stress response. Specifically, Hfq helps pair noncoding RNAs (ncRNAs) with complementary regions of target mRNAs. To probe the mechanism of this pairing, we generated a series of Hfq mutants and measured their affinity for RNAs like those with which Hfq must associate in vivo. We tested the...

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Identifiers

PMID: 15531892
DOI: 10.1038/nsmb858
PMCID: PMC3071270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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