Article

Despite of DNA repair ability the Fanconi anemia mutant protein FANCGR22P destabilizes mitochondria and leads to genomic instability via FANCJ helicase

2020-01-15

Abstract excerpt

<h4>Summary</h4> Fanconi anemia (FA) is a unique DNA damage repair pathway. Almost twenty-two genes have been identified which are associated with the FA pathway. Defect in any of those genes causes genomic instability, and the patients bear the mutation become susceptible to cancer. In our earlier work, we have identified that Fanconi anemia protein G (FANCG) protects the mitochondria from oxidative stress. In t...

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Literature Corpus work: 4922de62-9ae8-5e9d-9328-044044005bed
DOI: 10.1101/2020.01.15.907303

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Despite of DNA repair ability the Fanconi anemia mutant protein FANCGR22P destabilizes mitochondria and leads to genomic instability via FANCJ helicaseDOI 10.1101/2020.01.15.907303Read

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