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Article

Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1.

Molecular cancer research : MCR - 1 Jun 2021

Calvo Jennifer A, Fritchman Briana, Hernandez Desiree, Persky Nicole S, Johannessen Cory M, Piccioni Federica, Kelch Brian A, Cantor Sharon B

Abstract excerpt

FANCJ (BRIP1/BACH1) is a hereditary breast and ovarian cancer (HBOC) gene encoding a DNA helicase. Similar to HBOC genes, BRCA1 and BRCA2, FANCJ is critical for processing DNA inter-strand crosslinks (ICL) induced by chemotherapeutics, such as cisplatin. Consequently, cells deficient in FANCJ or its catalytic activity are sensitive to ICL-inducing agents. Unfortunately, the majority of FANCJ clinical mutations...

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Identifiers

PMID: 33619228
DOI: 10.1158/1541-7786.MCR-20-0828
PMCID: PMC8178215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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