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Article

The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.

The Journal of biological chemistry - 22 Jun 2012

Wu Yuliang, Sommers Joshua A, Loiland Jason A, Kitao Hiroyuki, Kuper Jochen, Kisker Caroline, Brosh Robert M

Abstract excerpt

The Q motif, conserved in a number of RNA and DNA helicases, is proposed to be important for ATP binding based on structural data, but its precise biochemical functions are less certain. FANCJ encodes a Q motif DEAH box DNA helicase implicated in Fanconi anemia and breast cancer. A Q25A mutation of the invariant glutamine in the Q motif abolished its ability to complement cisplatin or telomestatin sensitivity of...

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Identifiers

PMID: 22582397
DOI: 10.1074/jbc.M112.351338
PMCID: PMC3381133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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