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Article

Inactivation of APC Induces CD34 Upregulation to Promote Epithelial-Mesenchymal Transition and Cancer Stem Cell Traits in Pancreatic Cancer.

International journal of molecular sciences - 23 Jun 2020

Hsieh Mei Jen, Chiu Tai-Jan, Lin Yu Chun, Weng Ching-Chieh, Weng Yu-Ting, Hsiao Chang-Chun, Cheng Kuang-Hung

Abstract excerpt

Pancreatic cancer (PC) is a highly lethal malignancy due to the cancer routinely being diagnosed late and having a limited response to chemotherapy. Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic malignant tumor, representing more than 85% of all pancreatic cancers. In the present study, we characterized the phenotypes of concomitant P53 and APC mutations in pancreatic neoplasms...

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Share to Adenomatous Polyposis Coli Protein
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Pancreatic Ductal

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Share to Epithelial-Mesenchymal Transition

Share to Mice, SCID

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Share to Pancreatic Neoplasms

Source

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Identifiers

PMID: 32586050
DOI: 10.3390/ijms21124473
PMCID: PMC7352299

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