Article

Risk Stratification of Arrhythmogenic Consequences of Andersen-Tawil Syndrome Affecting Kir2.1-PIP2 Interactions

2026-05-18

Abstract excerpt

<h4>Background</h4> Andersen-Tawil syndrome type 1 (ATS1) is caused by loss-of-function mutations in KCNJ2 , which encodes the inward rectifier K + channel Kir2.1, a key determinant of I K1 . Impaired Kir2.1 destabilizes membrane excitability and predisposes to ventricular arrhythmias. Most ATS1 variants disrupt channel regulation by phosphatidylinositol 4,5-bisphosphate (PIP2), but whether specific mutations...

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Literature Corpus work: 4181fbc7-81e1-5653-a257-74b214ad39a9
DOI: 10.64898/2026.05.13.26353154

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