Article
Multi-trait Genome-Wide Analyses of the Brain Imaging Phenotypes in UK Biobank.
Genetics - 1 Aug 2020
Wu Chong
Abstract excerpt
Many genetic variants identified in genome-wide association studies (GWAS) are associated with multiple, sometimes seemingly unrelated, traits. This motivates multi-trait association analyses, which have successfully identified novel associated loci for many complex diseases. While appealing, most existing methods focus on analyzing a relatively small number of traits, and may yield inflated Type 1 error rates...
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