An adaptive and robust method for multi-trait analysis of genome-wide association studies using summary statistics.

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with human traits or diseases in the past decade. Nevertheless, much of the heritability of many traits is still unaccounted for. Commonly used single-trait analysis methods are conservative, while multi-trait methods improve statistical power by integrating association evidence across multiple traits. In contrast to...

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