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Article

Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Aug 2012

LaPash Daniels Christine M, Austin Elizabeth V, Rockney Danica E, Jacka Elizabeth M, Hagemann Tracy L, Johnson Delinda A, Johnson Jeffrey A, Messing Albee

Abstract excerpt

Alexander disease is a fatal neurodegenerative disease caused by dominant mutations in glial fibrillary acidic protein (GFAP). The disease is characterized by protein inclusions called Rosenthal fibers within astrocyte cell bodies and processes, and an antioxidant response mediated by the transcr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22855800
DOI: 10.1523/JNEUROSCI.1494-12.2012
PMCID: PMC3448488

Genes

GFAP
GCLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22855800-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease.PMID 22855800Read ↗

Normal and Pathological NRF2 Signalling in the Central Nervous SystemSemantic proximity Read ↗

Synergistic Effects of Glial Fibrillary Acidic Protein Mutation and Overexpression in the Pathogenesis of Alexander Disease.Semantic proximity Read ↗

Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Semantic proximity Read ↗

Alexander disease: models, mechanisms, and medicine.Semantic proximity Read ↗

Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease.Semantic proximity Read ↗

Astrocyte-to-Neuron Reprogramming via Neurogenin2: A Dual Strategy for Circuit Restoration and Antioxidant Defense in Congenital Blindness and DeafnessSemantic proximity Read ↗

Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.Semantic proximity Read ↗

The Nrf2-mediated defense mechanism associated with HFE genotype limits vulnerability to oxidative stress-induced toxicity.Semantic proximity Read ↗

Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairmentSemantic proximity Read ↗

Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.Semantic proximity Read ↗

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes.Semantic proximity Read ↗

Gfap Mutation and Astrocyte Dysfunction Lead to a Neurodegenerative Profile with Impaired Synaptic Plasticity and Cognitive Deficits in a Rat Model of Alexander Disease.Semantic proximity Read ↗

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