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Article

BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia.

Cancer science - 1 Apr 2024

Liu Jianwei, Isaji Tomoya, Komatsu Sachiko, Sun Yuhan, Xu Xing, Fukuda Tomohiko, Fujimura Tsutomu, Takahashi Shinichiro, Gu Jianguo

Abstract excerpt

Fms-like tyrosine kinase-3 (FLT3) is a commonly mutated gene in acute myeloid leukemia (AML). The two most common mutations are the internal-tandem duplication domain (ITD) mutation and the tyrosine kinase domain (TKD) mutation. FLT3-ITD and FLT3-TKD exhibit distinct protein stability, cellular localization, and intracellular signaling. To understand the underlying mechanisms, we performed proximity labeling with...

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Identifiers

PMID: 38288901
DOI: 10.1111/cas.16090
PMCID: PMC11007003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia.PMID 38288901Read ↗

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FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cellsSemantic proximity Read ↗

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