Article
A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation.
Leukemia - 1 Mar 2022
Yang Min, Pan Zengkai, Huang Kezhi, Büsche Guntram, Liu Hongyun, Göhring Gudrun, Rumpel Regina, Dittrich-Breiholz Oliver, Talbot Steven, Scherr Michaela, Chaturvedi Anuhar, Eder Matthias, Skokowa Julia, Zhou Jianfeng, Welte Karl, von Neuhoff Nils, Liu Ligen, Ganser Arnold, Li Zhixiong
Abstract excerpt
With an incidence of ~50%, the absence or reduced protein level of p53 is much more common than TP53 mutations in acute myeloid leukemia (AML). AML with FLT3-ITD (internal tandem duplication) mutations has an unfavorable prognosis and is highly associated with wt-p53 dysfunction. While TP53 mutation in the presence of FLT3-ITD does not induce AML in mice, it is not clear whether p53 haploinsufficiency or loss...
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