Article
Wnt signaling: a key regulator of bone mass.
Current topics in developmental biology - 1 Jan 2006
Baron Roland, Rawadi Georges, Roman-Roman Sergio
Abstract excerpt
The identification of a link between bone mass in humans and gain- [high bone mass (HBM) trait] or loss-of-function [osteoporosis pseudoglioma (OPPG) syndrome] mutations in the Wnt coreceptor lipoprotein receptor-related protein (LRP)5 or in the Wnt antagonist sclerostin (sclerosteosis, Van Buchem syndrome) has called the attention of academic and industry scientists and clinicians to the importance of this...
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