Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia.

Blood cancer journal - 11 Jun 2020

Österroos Albin, Björklund My, Eriksson Anna, Lindberg Johan, Nilsson Christer, Mareschal Sylvain, Rantalainen Mattias, Grönberg Henrik, Lehmann Sören

Abstract excerpt

Relevant molecular tools for treatment stratification of patients ≥65 years with acute myeloid leukemia (AML) are lacking. We combined clinical data with targeted DNA- and full RNA-sequencing of 182 intensively and palliatively treated patients to predict complete remission (CR) and survival in AML patients ≥65 years. Intensively treated patients with NPM1 and IDH2R172 mutations had longer overall survival (OS),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endodeoxyribonucleases
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Nucleophosmin

Share to Remission Induction

Share to Survival Analysis

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 32527994
DOI: 10.1038/s41408-020-0332-3
PMCID: PMC7289793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia.PMID 32527994Read ↗

Genomic Classification and Prognosis in Acute Myeloid Leukemia.Semantic proximity Read ↗

Molecular Characterization of the Highest Risk Adult Patients with Acute Myeloid Leukemia (AML) through Multi-omics ClusteringSemantic proximity Read ↗

Additional gene mutations may refine the 2017 European LeukemiaNet classification in adult patients with de novo acute myeloid leukemia aged <60 years.Semantic proximity Read ↗

Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older.Semantic proximity Read ↗

Prognostic utility of six mutated genes for older patients with acute myeloid leukemia.Semantic proximity Read ↗

A precision medicine classification for treatment of acute myeloid leukemia in older patients.Semantic proximity Read ↗

Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy.Semantic proximity Read ↗

Beat-AML 2024 ELN-refined risk stratification for older adults with newly diagnosed AML given lower-intensity therapy.Semantic proximity Read ↗

Integrative analysis of epigenetic subtypes in acute myeloid Leukemia: A multi-center study combining machine learning for prognostic and therapeutic insightsSemantic proximity Read ↗

Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia.Semantic proximity Read ↗

A targeted next-generation sequencing in the molecular risk stratification of adult acute myeloid leukemia: implications for clinical practice.Semantic proximity Read ↗

Translational Research on Azacitidine Post- Remission Therapy of Acute Myeloid Leukemia in Elderly Patients (QOL-ONE Trans-2)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.